| 1 |
06/01/2007 |
17373721 |
Mutational analysis of SPANX genes in families with X-linked prostate cancer. |
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BACKGROUND: Previous genetic linkage studies identified a locus for susceptibility to prostate cancer called HPCX at Xq27. The candidate region contains two clusters of SPANX genes. The first cluster ...
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| 2 |
11/01/2006 |
17012309 |
Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. |
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Human sperm protein associated with the nucleus on the X chromosome consists of a five-member gene family (SPANXA1, SPANXA2, SPANXB, SPANXC and SPANXD) clustered at Xq27.1. Evolved from an ancestral S...
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| 3 |
08/01/2005 |
15906096 |
A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region. |
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BACKGROUND: Prostate cancer (PRCA) is the most common cancer in males in the western world. In Finland PRCA has an age-adjusted incidence of 81.5 per 100,000. We previously reported that in Finland, t...
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| 4 |
10/15/2004 |
15501973 |
The spontaneous CD8+ T-cell response to HLA-A2-restricted NY-ESO-1b peptide in hepatocellular carcinoma patients. |
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PURPOSE: Hepatocellular carcinoma (HCC) can express various cancer-testis antigens including NY-ESO-1, members of the SSX family, members of the MAGE family, SCP-1, and CTP11. Immunotherapy directed a...
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| 5 |
07/15/2004 |
15237429 |
Expression of cancer-testis antigens in hepatocellular carcinoma. |
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AIM: To investigate the expression of cancer-testis (CT) antigens MAGE-1, SSX-1,CTp11 and HCA587 genes in hepatocellular carcinoma (HCC) and the possibility of applying these antigens as targets for s...
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| 6 |
05/08/2003 |
12758128 |
The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. |
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Multigenicity is one of the features of cancer/testis-associated genes. In the present study we analyzed the number and expression of genes of the SPANX(CTp11) family of cancer/testis-associated genes...
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| 7 |
06/15/2001 |
11397121 |
NY-ESO-1 and CTp11 expression may correlate with stage of progression in melanoma. |
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BACKGROUND: As tumor cells spread beyond their primary site they undergo changes in their gene expression that may be detectable and useful for microstaging. The cancer/testis (CT) antigens are a fami...
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| 8 |
01/01/2001 |
11133693 |
Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. |
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Cancer-testis antigens (CTAs) represent potential targets for cancer immunotherapy because these proteins are widely distributed in tumors but not in normal tissues, except testes. In this paper, we i...
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| 9 |
12/15/1999 |
10626816 |
CTp11, a novel member of the family of human cancer/testis antigens. |
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To identify new genes that may contribute to the metastatic pathway of neoplastic cells, we compared mRNA expression of the parental human melanoma cell line 1F6 and its metastatic variant 1F6m using ...
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