Gene

Gene:

MAGEA1 (official gene symbol)

Other symbol:

MAGEA1

CT family:

CT1

CT identifier:

CT1.1

Aliases from NCBI:

MAGE1 , MGC9326

RefSeq

Nucleotide : NM_004988.4

Phylogenetic relationships with CT genes

This gene belongs to the MAGE family, sub-family MAGEA.

Gene Identification

MAGEA1 was the first molecularly characterized human tumor antigen recognized by cytotoxic T cells. Initially, a MAGEA-1 antigen, denominated E antigen, was identified by selecting sub clones from the MZ2-MEL cell line, derived from a melanoma patient, which are resistent to lysis by autologous lymphocyte derived CTLs (Van den Eynde et al, 1989 PMID: 2529220). Afterwards, the gene encoding antigen E was identified by T cell epitope cloning (van der Bruggen et al., 1991 PMID: 1840703; Traversari et al., 1992 PMID: 1402688; Coulie et al, 1993 PMID: 8280701).

Gene structure and chromosomal localization

MAGEA-1 was mapped to the Xq28 region by in situ hybridization of metaphase spreads using a MAGEA-1 probe (Wang et al, 1994 PMID: 8039421).

Chromosome band: Xq28

See this gene in the UCSC Genome Browser :

See this gene in the NCBI Map Viewer Genome Browser :

Exon-intron structure and splicing variants

Splicing variants documented by RefSeqs:

SNPs

Show

ACCESSION	ALLELES	HET	SE_HET	FXN_CLASS	RESIDUE	AA_POSITION	VALIDATED
rs2008144	A/G	0.378131	0.214668	missense	Q	71	YES
rs2008144	A/G	0.378131	0.214668	reference	R	71	YES
rs2008160	A/G	0.48664	0.0806315	reference	T	31	YES
rs2008160	A/G	0.48664	0.0806315	missense	A	31	YES
rs2187645	A/G	0.0102561	0.0708723	reference	S	167	YES
rs2187645	A/G	0.0102561	0.0708723	coding-synonymous	S	167	YES
rs2233044	A/G	0.00990075	0.0696588	missense	T	62	YES
rs2233044	A/G	0.00990075	0.0696588	reference	A	62	YES

CTDatabase

User logged:

List of genes: