Immune response
Gene:
MAGEA4 (official gene symbol)Other symbol:
MAGEA4CT family:
CT1CT identifier:
CT1.4Aliases from NCBI:
MAGE-41 , MAGE-X2 , MAGE4 , MAGE4A , MAGE4B , MGC21336Humoral immune response
MAGEA4 was identified by SEREX (Chen et al., 1998).
Spontaneous humoral immune responses against MAGEA4 have been detected in cancer patients.
| Tumor type | Tumor stage | Frequency | Antibody detection methodology | PMID |
|---|---|---|---|---|
| Adult T-cell leukemia/lymphoma (ATLL) | 0/43 (0%) | ELISA | 22323448 | |
| Non-Hodgkin�s lymphoma | 5/97 (5%) | ELISA | 22638551 |
Cellular immune response
CD4 T-cell responses against MAGEA4 were observed in in head and neck squamous cell carcinoma patients (Cesson et al., 2010 PMID: 20857101). MAGE-A4-specific CD8 and CD4 T cells were expanded from healthy donors and Hodgkin lymphoma patients (Cruz et al., 2011 PMID: 21908573). CD8+ T cell epitope derived from MAGEA4 was identified in esophageal carcinoma (Wu et al., 2011 PMID: 21815906).
The following MAGEA4 epitopes recognized by T cells have been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
| HLA | HLA Frequency (%) | Peptide | Position | Lymphocyte Stimulation Method |
PMID |
|---|---|---|---|---|---|
| A1 | 26 | EVDPASNTY | 169-177 | peptide after tetramer sorting | 14617050 |
| A2 | 44 | GVYDGREHTV | 230-239 | adeno-dendritic cells | 10540345 |
| A24 | 20 | NYKRCFPVI | 143-151 | peptide | 16061876 |
| B37 | 3 | SESLKMIF | 156-163 | poxvirus-dendritic cells | 12492812 |
Induced immune response
Studies that demonstrated induction of immune responses in patients immunized with MAGEA4.
| Immunogen | PMID |
|---|---|
| Dendritic cells pulsed with MAGEA4 peptides |