Protein expression
Gene:
MAGEA4 (official gene symbol)Other symbol:
MAGEA4CT family:
CT1CT identifier:
CT1.4Aliases from NCBI:
MAGE-41 , MAGE-X2 , MAGE4 , MAGE4A , MAGE4B , MGC21336Published data of protein expression in normal tissues
Show| Tissue | Methodology | PMID |
|---|---|---|
| Testis | IHC | 17148558 |
| Fetal ovary | IHC | 17274819 |
| Fetal testis | IHC mAB 57B | 11753951 |
| Fetal testis | IHC | 15317684 |
| Fetal testis | IHC | 16210381 |
| Testis | Tissue microarray (mAB 57B) | 12454517 |
| Fetal adrenal gland | Tissue microarray (mAB 57B) | 12454517 |
| Placenta | Tissue microarray (mAB 57B) | 12454517 |
| Vagina | Tissue microarray (mAB 57B) | 12454517 |
Published data of protein expression in neoplasias
Hematologic malignacies Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Extramedullary plasmacytoma |
3/4 (75%) | IHC mAB 57B | 12875607 | |
| Myeloma |
1/13 (7.7%) | IHC mAB 57B | ||
| Plasmacytoma |
2/12 (16.7%) | IHC mAB 57B | ||
| Plasma cell myeloma |
20/166 (11%) | IHC | 18307538 |
Bladder cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Adenocarcinoma |
1/ 1 (100%) | IHC | 19533752 | |
| Sarcomatoid carcinoma |
2/4 (50%) | IHC | ||
| Small cell carcinoma |
0/1 (0%) | IHC | ||
| Squamous carcinoma |
13/19 (68%) | IHC | ||
| Transitional cell carcinoma |
175/418 (42%) | IHC |
Brain cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Medulloblastomas |
1/25 (4%) | IHC mAB 57B | 18426187 | |
| Astrocytoma |
0/25 (0%) | Tissue microarray (mAB 57B) | 12454517 | |
| Ependymoma |
0/12 (0%) | Tissue microarray (mAB 57B) | ||
| Glioblastoma multiforme |
0/39 (0%) | Tissue microarray (mAB 57B) | ||
| Schwanoma |
0/38 (0%) | Tissue microarray (mAB 57B) |
Breast cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Breast carcinoma |
Primary invasive | 6/140 (4%) | Tissue microarray (IHC) | 23731661 |
Gastric cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Gastrointestinal stromal tumor (GIST) |
11/86 (13%) | IHC | 21140451 |
Gynecological cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Vulvar squamous cell carcinoma |
Lymphnode metastasis | 25/32 (78%) | IHC | 21323970 |
| Vulvar squamous cell carcinoma |
Primary tumor | 52/76 (69%) | IHC |
Head & Neck cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Squamous cell carcinoma of the larynx |
38/63 (60%) | IHC | 20886663 | |
| Oral squamous cell carcinoma |
13/23 (56%) | IHC | 22083937 |
Lung cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Adenocarcinoma |
0/4 (0%) | IHC mAB 6C1 | 16651421 | |
| Squamous cell carcinoma |
3/4 (75%) | IHC mAB 6C1 | ||
| Adenocarcinoma |
12/65 (18%) | Tissue microarray (mAB 57B) | 12454517 | |
| Large cell carcinoma |
16/38 (42%) | Tissue microarray (mAB 57B) | ||
| Squamous cell carcinoma |
97/178 (54%) | Tissue microarray (mAB 57B) |
Melanocytic lesion Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Melanoma |
Primary tumor | 11 ⁄ 38 (29%) | IHC mAB 57B | 15606517 |
| Nevus |
0/19 (0%) | IHC mAB 57B | ||
| Melanoma |
Oesophageal mucosa | 6/6 (100%) | IHC mAB 57B | 14646623 |
| Desmoplastic melanoma |
Epithelioid component | 1/31 (5%) | IHC mAB 57B | 10890380 |
| Desmoplastic melanoma |
Spindle cell component | 4/32 (13%) | IHC mAB 57B | |
| Desmoplastic melanoma |
Junctional component | 5/20 (20%) | IHC mAB 57B | |
| Melanoma |
17/60 (28%) | Tissue microarray (mAB 57B) | 12454517 | |
| Melanoma |
58/321 (18%) | IHC | 21115342 |
OTHER CANCER Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Gastrointestinal stromal tumor (GIST) |
5/35 (14%) | IHC | 19190130 |
Ovarian cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Dysgerminoma |
7/17 (40%) | IHC | 17274819 | |
| Serous carcinoma |
30 /53 (56.6%) | IHC mAB 57B | 14695148 | |
| Serous cystadenomas |
0/10 (0%) | IHC mAB 57B | ||
| Serous tumor of borderline malignancy |
1/11 (9.1%) | IHC mAB 57B | ||
| Adenocarcinoma |
1/8 (12%) | Tissue microarray (mAB 57B) | 12454517 | |
| Malignant mullerian mixed tumor |
3/5 (60%) | Tissue microarray (mAB 57B) | ||
| Mucinous ovarian carcinoma |
0/4 (0%) | Tissue microarray (mAB 57B) | ||
| Ovarian carcinoma |
0/4 (0%) | Tissue microarray (mAB 57B) | ||
| Serous ovarian tumor |
8/44 (18%) | Tissue microarray (mAB 57B) | ||
| Ovarian carcinoma |
Recurrent tumor | 18/80 (23%) | IHC | 23529156 |
| Ovarian carcinoma |
Primary tumor | 52/230 (23%) | IHC |
Sarcoma Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Gastrointestinal stromal tumor (GIST) |
5/35 (14%) | IHC | 18646188 |
Testicular cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Testicular germ cell tumors |
Seminal fluid | 47/57 (82%) | IHC | 19207618 |
Published data of protein expression in Cell Lines
Show| Origin tissue | Cell Line ID | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Melanoma | Ma-Mel-22 UKRV-Mel-06 UKRV-Mel-10 UKRV-Mel-31 |
4/15 (27%) | SEREX | 12932233 |
Available antibodies
R5 monoclonal antibody Takahashi et al., 1995 PMID: 7627949
anti-MAGE4 polyclonal antibody Takahashi et al., 1995 PMID: 7627949
57B monoclonal antibody Yakirevich et al., 2003 PMID: 12610355
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