Protein

Gene:

MAGEA4 (official gene symbol)

Other symbol:

MAGEA4

CT family:

CT1

CT identifier:

CT1.4

Aliases from NCBI:

MAGE-41 , MAGE-X2 , MAGE4 , MAGE4A , MAGE4B , MGC21336

RefSeq :

NP_002353.3 | NP_001011550.1 | NP_001011549.1 | NP_001011548.1

Protein Names (UNIPROT)

Melanoma-associated antigen 4

Cellular localization

Subcellular Localization	Cell type	Methodology	PMID
nucleus and cytoplasm	spermatogonia and primary spermatocytes	IHC	12610355
nucleus and cytoplasm	spermatogonia and primary spermatocytes	IHC	7627949

Protein function and interaction

MAGEA4 C terminal region binds to the oncoprotein gankyrin and appears to supress its oncogenic activity (Nagao et al., 2003). MAGEA4 C terminal region also binds Miz-1 and it is suggested that this interaction has pro apoptotic activity (Sakurai et al., 2004).

MAGE family proteins may enhance ubiquitin ligase activity through recruitment and/or stabilization of the E2 ubiquitin conjugating enzymes at the E3-substrate complex (Doyle et al, 2010 PMID: 20864041).