Protein
Gene:
MAGEA3 (official gene symbol)Other symbol:
MAGEA3CT family:
CT1CT identifier:
CT1.3Aliases from NCBI:
HIP8 , HYPD , MAGE3 , MGC14613RefSeq :
Protein Names (UNIPROT)
Melanoma-associated antigen 3
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| cytoplasm | gastrict tumor cells | IHC | 11289403 |
| cytoplasm | hepatocellular carcinoma cells | IHC | 10576668 |
| cytoplasm | intrahepatic cholangiocarcinoma cells | IHC | 15466353 |
| cytoplasm | MZ-2 melanoma cell line | IHC | 7757970 |
Protein function and interaction
MAGEA3 binds to TRIM28, which belongs to the TRIM family of E3 RING ubiquitin ligases. This interaction may enhance ubiquitin ligase activity through recruitment and/or stabilization of the E2 ubiquitin conjugating enzymes at the E3-substrate complex (Doyle et al, 2010 PMID: 20864041).
The expression of MageA3 is induced by Helicobacter pylori in a mouse cell line (Fukuyama et al., 2012 PMID:22773374).
MAGE-A proteins interact with p53 proteins and MAGE-A family proteins may block the association of p53 with its cognate sites in chromatin (Marcar et al., 2010 PMID: 21056992).
