| 1 |
02/01/2007 |
17023585 |
Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. |
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Immunotherapies using cancer-testis (CT) antigens as targets represent a potentially useful treatment in patients with multiple myeloma (MM) who commonly show recurrent disease following chemotherapy....
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| 2 |
09/01/2006 |
16929165 |
Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. |
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Cancer-Testis (CT) antigens are by definition expressed in tumor but not in healthy tissue except testis and might represent ideal targets for antigen-specific immunotherapy. Here, we present the firs...
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| 3 |
06/20/2006 |
16782924 |
Prospective multi-institutional study of reverse transcriptase polymerase chain reaction for molecular staging of melanoma. |
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PURPOSE: To evaluate the prognostic significance of molecular staging using reverse transcriptase polymerase chain reaction (RT-PCR) in detecting occult melanoma cells in sentinel lymph nodes (SLNs) a...
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| 4 |
06/13/2006 |
16854286 |
[Effects of expression silencing of MAGE3 by RNA interference on location and metastasis of lung carcinoma cells] |
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OBJECTIVE: To construct small interfering RNA (siRNA) expression vectors targeting human MAGE3 gene and to observe the effects of gene silencing of MAGE3 by RNA interference on location and metastasis...
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| 5 |
05/01/2006 |
16331618 |
The clinical significance of MAGEA3 expression in pancreatic cancer. |
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The MAGEA gene family that encodes cancer testis antigens is differentially expressed in many cancers. Though MAGEA3 expression has been detected in gastrointestinal malignancies, its role in pancreat...
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| 6 |
03/01/2006 |
16507254 |
[Preliminary study of LFn-MAGE3 fusion protein expression and its biological function] |
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AIM: To explore the possibility of using the nontoxic form of anthrax toxin in cancer immunotherapy by LFn-MAGE3 fusion protein expression. METHODS: A fusion expression vector named PET21a-LFn was con...
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| 7 |
11/01/2005 |
16305960 |
[Construction of standard recombinant plasmids for 7 common mannan-binding lectin gene haplotypes] |
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OBJECTIVE: To construct the standard recombinant plasmids for 7 common haplotypes of mannan-binding lectin (MBL) gene. METHODS: The DNA samples with known haplotypes and genotypes of MBL gene were use...
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| 8 |
10/15/2005 |
16116595 |
Molecular classification of melanoma using real-time quantitative reverse transcriptase-polymerase chain reaction. |
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BACKGROUND: The early detection and characterization of metastatic melanoma are important for prognosis and management of the disease. Molecular methods are more sensitive in detecting occult lymph no...
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| 9 |
10/01/2005 |
16163672 |
Assessment of CD8 involvement in T cell clone avidity by direct measurement of HLA-A2/Mage3 complex density using a high-affinity TCR like monoclonal antibody. |
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Peptide affinity for MHC molecules determines the number of MHC/peptide complexes stabilized at the cell surface in in vitro tests or in vaccination protocols. We isolated a high affinity monoclonal a...
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| 10 |
05/01/2005 |
15672408 |
Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors. |
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Testicular germ-cell tumors (TGCTs) are pluripotent and display protean histology from the germ-cell stage until embryonal and somatic-cell differentiation. These properties make TGCT a fascinating mo...
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| 11 |
03/02/2005 |
15740633 |
Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial. |
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BACKGROUND: DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and s...
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| 12 |
01/01/2005 |
16319511 |
Generation of antigen-presenting cells using cultured dendritic cells and amplified autologous tumor mRNA. |
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Novel antigen-presenting cells (APCs) were generated using cultured dendritic cells (DCs) and amplified tumor mRNA, and the potential of tumor antigen-reactive T cell induction by the tumor RNA-introd...
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| 13 |
03/01/2004 |
15160996 |
Cytotoxic T cell induction against human malignant melanoma cells using HLA-A24-restricted melanoma peptide cocktail. |
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Many human leukocyte antigen (HLA)-class I (mainly A*0201)-restricted peptide-specific cytotoxic T cells (CTLs) have been derived from peripheral blood lymphocytes (PBLs) of melanoma patients. However...
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| 14 |
10/01/2003 |
12964025 |
Dendritic cell vaccine immunotherapy of cancer targeting MUC1 mucin. |
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The use of dendritic cells (DCs) for cancer vaccination is effective in suppressing cancer progression. This is because the DCs play a crucial role in priming tumor-specific immunity efficiently as an...
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| 15 |
07/01/2003 |
12855658 |
Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines. |
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Previous studies directed at identifying paclitaxel resistance genes in a paclitaxel-resistant subclone of the human ovarian cancer cell line SKOV-3 identified a novel cancer testis antigen, Taxol res...
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| 16 |
05/01/2003 |
12806279 |
Generation of melanoma-specific cytotoxic T lymphocytes for allogeneic immunotherapy. |
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To exploit alloreactive T-cell responses known as the graft-versus-tumor effect, allogeneic hematopoietic stem cell transplantation is being explored as experimental therapy in selected solid tumors, ...
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| 17 |
01/01/2003 |
14609222 |
Dendritic cells: controllers of the immune system and a new promise for immunotherapy. |
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Dendritic cells (DCs) can be utilized either as vectors or as targets for therapy. Patients with metastatic melanoma received CD34-DC vaccine that contains Langerhans' cells and interstitial DCs. DCs ...
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| 18 |
09/01/2002 |
12242516 |
Induction of specific CTL by MAGE-3/CEA peptide-pulsed dendritic cells from HLA-A2/A24(+) gastrointestinal cancer patients. |
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PURPOSE: In this study, we aimed to investigate whether MAGE3/CEA peptide-pulsed dendritic cells could induce specific cytotoxic T lymphocytes (CTL). METHODS: In this pilot study, we selected 25 patie...
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| 19 |
07/15/2002 |
12124339 |
Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets. |
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Monitoring human antibody recognition of tumor antigens could have potential diagnostic and prognostic significance. Serological analysis of recombinant cDNA expression libraries of human cancer has i...
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| 20 |
07/01/2002 |
12378152 |
[Antitumor vaccines: conception, development and evaluation in humans] |
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Our strategy is to develop multivalent recombinant vaccines capable of eliciting broad immune responses in patients with malignant melanoma or colorectal cancer. Our current focus is on the induction ...
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