Immune response
Gene:
MAGEC1 (official gene symbol)Other symbol:
MAGEC1CT family:
CT7CT identifier:
CT7.1Aliases from NCBI:
CT7 , MAGE-C1 , MGC39366Humoral immune response
MAGEC1 was identified by SEREX and may elicit spontaneous humoral immune responses in cancer patients (Chen et al., 1998).
| Tumor type | Tumor stage | Frequency | Antibody detection methodology | PMID |
|---|---|---|---|---|
| Myeloma | 30/60 (50%) | Western blot | 18323799 | |
| Monoclonal gammopathy of undetermined significance (MGUS) | 2/4 (50%) | Western blot | 18323799 | |
| Light-chain amyloidosis (AL amyloidosis) | 0/35 (0%) | ELISA | 22983433 |
Cellular immune response
Bone marrow lymphocytes from untreated multiple myeloma patients exhibited MAGEC1-specific cellular immune responses as measured by an autologous cellular immunity assay (Lendvai et al., 2010 PMID: 20108890). CT7-specific CD4(+) T-cell responses were detected in melanoma patients (Nuber et al., 2010 PMID: 20696919). Immunogenic CD8(+) T-cell epitopes of MAGE-C1 (CT-7) were identified by Anderson et al., (2011 PMID: 21461886).
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with MAGEC1.