Protein
Gene:
MAGEC1 (official gene symbol)Other symbol:
MAGEC1CT family:
CT7CT identifier:
CT7.1Aliases from NCBI:
CT7 , MAGE-C1 , MGC39366RefSeq :
Protein Names (UNIPROT)
Melanoma-associated antigen C1
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| nucleus and cytoplasm | plasma cell myeloma cell line ARK | Immunofluorescence | 18307538 |
| cytoplasm | spermatogonia | Immunofluorescence | 18307538 |
| cytoplasm | spermatogonia and primary spermatocytes | IHC | 22016418 |
Protein function and interaction
MAGE family proteins may enhance ubiquitin ligase activity through recruitment and/or stabilization of the E2 ubiquitin conjugating enzymes at the E3-substrate complex (Doyle et al, 2010 PMID: 20864041).
The MHD (MAGE homology domain) of MAGE-C1 interacts with NY-ESO-1 (Cho et al, 2006 PMID: 17137291).
