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List of genes:

Pubmed

Gene: 

ADAM2 (official gene symbol)

Other symbol: 

ADAM2

CT family: 

CT15 

CT identifier: 

CT15

Aliases from NCBI:

CRYN1 , CRYN2 , FTNB , PH-30b , PH30

24 records found.
2 pages with 20 records each.
Show page 2 of 2.
   

ARTICLE DATE PUBMED ID TITLE GENES
1 06/15/2007 17439939 Identification of an ADAM2-ADAM3 complex on the surface of mouse testicular germ cells and cauda epididymal sperm.
  Male mice lacking ADAM2 (fertilin beta) or ADAM3 (cyritestin) are infertile; cauda epididymal sperm (mature sperm) from these mutant mice cannot bind to the egg zona pellucida. ADAM3 is barely present...
2 02/01/2007 17023585 Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation.
  Immunotherapies using cancer-testis (CT) antigens as targets represent a potentially useful treatment in patients with multiple myeloma (MM) who commonly show recurrent disease following chemotherapy....
3 01/01/2007 17644977 Sperm-egg interaction and gene manipulated animals.
  It is intriguing that the disruption of a number of genes, e.g., Clgn, Ace, Adamla, Adam2 and Adam3 results in a similar sperm phenotype, i.e., failure of sperm to bind to the zona pellucida (ZP). Bec...
4 11/01/2006 16870943 Aberrant distribution of ADAM3 in sperm from both angiotensin-converting enzyme (Ace)- and calmegin (Clgn)-deficient mice.
  Male mice deficient for the calmegin (Clgn) or the angiotensin-converting enzyme (Ace) gene show impaired sperm migration into the oviduct and loss of sperm-zona pellucida binding ability in vitro. Si...
5 09/01/2006 16929165 Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma.
  Cancer-Testis (CT) antigens are by definition expressed in tumor but not in healthy tissue except testis and might represent ideal targets for antigen-specific immunotherapy. Here, we present the firs...
6 04/01/2006 16407499 Expression and relationship of male reproductive ADAMs in mouse.
  A number of a disintegrin and metalloprotease (ADAM) family members are expressed in mammalian male reproductive organs such as testis and epididymis. These reproductive ADAMs are divided phylogenical...
7 03/03/2006 16407235 Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization.
  Fertilin, a heterodimeric protein complex composed of alpha (ADAM1) and beta (ADAM2) subunits on the sperm surface, is believed to mediate adhesion and fusion between the sperm and egg plasma membrane...
8 11/01/2005 16014818 Defects in secretory pathway trafficking during sperm development in Adam2 knockout mice.
  Adam2-null and Adam3-null male mice exhibit reduced levels of one or more ADAM proteins on mature sperm, in addition to the loss of the genetically targeted protein. ADAM protein loss was believed to ...
9 06/01/2005 16035044 The ADAM-integrin-tetraspanin complex in fetal and postnatal testicular cords.
  New insights have emerged about the expression, during testicular cord formation, of the ADAM (a disintegrin and metalloprotease) domain family of proteins that combines both cell surface adhesion and...
10 08/13/2004 15194697 Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface.
  In mouse, two different isoforms of ADAM1 (fertilin alpha), ADAM1a and ADAM1b, are produced in the testis. ADAM1a is localized within the endoplasmic reticulum of testicular germ cells, whereas epidid...
11 10/01/2003 14510675 Chromosomal mapping, sequence and transcription analysis of the porcine fertilin beta gene (ADAM2).
  Fertilin beta (ADAM2) forms a part of the heterodimeric surface protein fertilin, found on the plasma membrane of mammalian sperm, and has been implicated in the process of sperm-egg fusion. Analysis ...
12 07/01/2003 12815633 Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2).
  Immediately after birth, primordial germinal cell-derived prespermatogonia (PSG), located in the center of the testicular cords, migrate between adjacent Sertoli cells to establish contact with the co...
13 05/02/2003 12711316 Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
  Although fertilin is a heterodimeric complex between ADAM1 (A Disintegrin And Metalloprotease 1, fertilin alpha) and ADAM2 (fertilin beta) located on the sperm surface, two different ADAM1 isoforms, A...
14 01/30/2003 12568724 Identification and characterization of ADAM32 with testis-predominant gene expression.
  Members of the ADAM (A Disintegrin And Metalloprotease) family of cell surface proteins have been discovered in a variety of tissues and species. We have cloned and sequenced a mouse cDNA encoding a n...
15 11/01/2002 12411606 Mammalian sperm proteins are rapidly evolving: evidence of positive selection in functionally diverse genes.
  A growing number of genes involved in sex and reproduction have been demonstrated to be rapidly evolving. Here, we show that genes expressed solely in spermatozoa represent a highly diverged subset am...
16 07/01/2002 12206465 The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization.
  Gamete membrane interactions begin with adhesion (binding) of the sperm to the oocyte plasma membrane and culminate with fusion of the membranes of the gametes, thus creating the zygote through the un...
17 05/17/2002 11882657 Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.
  ADAMs (a disintegrin and metalloproteases) are members of the metzincin superfamily of metalloproteases. Among integrins binding to disintegrin domains of ADAMs are alpha(9)beta(1) and alpha(v)beta(3)...
18 04/01/2002 11920606 Identification of cancer/testis genes by database mining and mRNA expression analysis.
  Cancer/testis (CT) antigens are immunogenic proteins expressed predominantly in gametogenic tissue and cancer; they are considered promising target molecules for cancer vaccines. The identification of...
19 07/01/2001 11462216 Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.
  One of the most important cell-cell interactions is that of the sperm with the egg. This interaction, which begins with cell adhesion and culminates with membrane fusion, is mediated by multiple molec...
20 03/17/2000 10713078 Identification of key functional amino acids of the mouse fertilin beta (ADAM2) disintegrin loop for cell-cell adhesion during fertilization.
  Fertilin beta (also known as ADAM2) is a cell adhesion molecule on the surface of mammalian sperm that participates in sperm-egg membrane binding. Fertilin beta is a member of the molecular family kno...