Protein
Gene:
MAGEA1 (official gene symbol)Other symbol:
MAGEA1CT family:
CT1CT identifier:
CT1.1Aliases from NCBI:
MAGE1 , MGC9326RefSeq :
Protein Names (UNIPROT)
Melanoma-associated antigen 1
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| cytoplasm | female germ cells | IHC | 17208940 |
| cytoplasm and axons | fetal neuron | IHC | 18611917 |
| nucleus and cytoplasm | Hela cells | subcellular fractionation | 15316101 |
| cytoplasm | male fetal germ cells | IHC | 17208940 |
| cytoplasm | melanoma cell lines | Immunofluorescence | 7980533 |
| cytoplasm | spermatogonia and primary spermatocytes | IHC | 10945497 |
| nucleus and cytoplasm | spermatogonia and primary spermatocytes | IHC | 7627949 |
| nucleus and cytoplasm | spermatogonia and primary spermatocytes | IHC | 22016418 |
Protein function and interaction
MAGEA1 can act as a transcriptional repressor. The interaction of MAGEA1 with the SKIP-interacting transactivator inhibits its function and presumably represses transcription. MAGEA1 is also able to block transcription by binding and recruiting histone deacetylase 1 (HDAC1) (Laduron et al., 2004 PMID: 15316101). Supression of MAGEA1 using small interfering RNA (siRNA) arrests growth of tumor cells, diminishes proliferation and induces apoptosis in human and murine mast cells (Yang et al., 2007 PMID: 17942928). These results indicate that MAGEA1 could possibly act regulating expression of genes involved in tumor cell growth or spermatogenesis.
MAGE-A proteins inhibit p53 function by blocking its interaction with chromatin and may suppress the p53 transcriptional program during tumor development (Marcar et al., 2010 PMID: 21056992).
MAGE family proteins may enhance ubiquitin ligase activity through recruitment and/or stabilization of the E2 ubiquitin conjugating enzymes at the E3-substrate complex (Doyle et al, 2010 PMID: 20864041).
