Protein expression
Gene:
MAGEA1 (official gene symbol)Other symbol:
MAGEA1CT family:
CT1CT identifier:
CT1.1Aliases from NCBI:
MAGE1 , MGC9326Published data of protein expression in normal tissues
Show| Tissue | Methodology | PMID |
|---|---|---|
| Testis | IHC | 7627949 |
| Fetal testis | IHC mAB #23 (Transduction Labs) | 17208940 |
| Testis | IHC mAB 57B | 10945497 |
| Fetal ovary | IHC mAB #23 (Transduction Labs) | 17208940 |
| Fetal neuron | IHC | 18611917 |
| Fetal spinal cord | IHC | 18611917 |
| Fetal testis | IHC | 22016418 |
| Fetal ovary | IHC | 22016418 |
| Testis (pre-meiotic germ cells) | IHC | 22016418 |
Published data of protein expression in neoplasias
Hematologic malignacies Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Classical Hodgkin’s lymphoma |
7/38 (18%) | Tissue microarray (IHC) | 21898529 | |
| Diffuse large B-cell testicular lymphoma |
3/24 (12%) | IHC | 23680437 |
Brain cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Glioblastoma |
16/53 (38%) | FACS | 15256472 | |
| Schwanoma |
1/16 (6%) | IHC mAB MA454 | 11756773 | |
| Medulloblastomas |
46% | IHC | 18377306 | |
| Medulloblastomas |
1/25 (4%) | IHC mAB MA454 | 18426187 |
Breast cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Breast carcinoma |
Metastatic tumor | 33/53 (62%) | IHC | 19651608 |
| Breast carcinoma |
Primary tumor | 28/201 (14%) | IHC | |
| Invasive ductal carcinoma |
ER-negative tumors | 65/265 (24%) | IHC | 21437249 |
| Invasive ductal carcinoma |
ER/PR/HER2 triple-negative tumors | 54/225 (24%) | IHC | |
| Invasive ductal carcinoma |
ER-positive tumors | 12/189 (6%) | IHC | |
| Breast carcinoma |
BRCA-associated tumors | 13/26 (50%) | IHC | 21465317 |
| Medullary breast cancer |
16/49 (33%) | IHC | 21495200 | |
| Breast carcinoma |
Primary invasive | 21/140 (15%) | Tissue microarray (IHC) | 23731661 |
Gastric cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Gastrict carcinoma |
Metastatic tumor | 26/96 (27%) | IHC | 20409582 |
| Gastrict carcinoma |
Primary tumor | 44/135 (33%) | IHC | |
| Gastrointestinal stromal tumor (GIST) |
8/86 (9%) | IHC | 21140451 |
Gynecological cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Vulvar squamous cell carcinoma |
Lymphnode metastasis | 25/32 (78%) | IHC | 21323970 |
| Vulvar squamous cell carcinoma |
Primary tumor | 52/76 (69%) | IHC |
Head & Neck cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Pharyngeal squamous cell carcinoma |
63/90 (70%) | IHC | 20029985 | |
| Squamous cell carcinoma of the larynx |
30/63 (48%) | IHC | 20886663 |
Hepatobiliary cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Hepatocellular carcinoma |
12/15(80%) | Western blot | 10576668 | |
| Intrahepatic cholagiocarcinoma |
26/89 (29%) | IHC | 21211023 |
Lung cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Lung carcinoma |
21/64 (33) | IHC mAB MA454 | 16773077 |
Melanocytic lesion Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Melanoma |
Primary tumor | 8 ⁄ 38 (21%) | IHC mAB MA454 | 15606517 |
| Nevus |
0 /19 (0%) | IHC mAB MA454 | ||
| Melanoma |
Oesophageal mucosa | 6/6 (100%) | IHC mAB MA454 | 14646623 |
| Desmoplastic melanoma |
Epithelioid component | 3/31 (9.7%) | IHC | 16845331 |
| Desmoplastic melanoma |
Junctional component | 4/20 (20%) | IHC | |
| Desmoplastic melanoma |
Spindle cell component | 4/32 (12.5%) | IHC | |
| Melanoma |
5/24 (21%) | IHC mAB MA454 (Lab Vision) | 16773077 | |
| Melanoma |
Metastatic tumor | 170/335 (51%) | IHC mAB MA454 | 16467087 |
| Melanoma |
Primary tumor | 50/251 20% | IHC mAB MA454 | |
| Melanoma |
Metastatic tumor | 7/10 (70%) | IHC mAB 57B | 10699915 |
| Desmoplastic melanoma |
3/8 (38%) | IHC mAB MA454 | 11756773 | |
| Epithelioid melanoma |
3/8 (38%) | IHC mAB MA454 | ||
| Spindle or epithelioid melanoma |
11/14 (79%) | IHC mAB MA454 | ||
| Melanoma |
28/37 (75%) | IHC mAB 77B | 8917707 | |
| Melanoma |
Metastatic tumor | 30/120 (25%) | IHC mAB 57B | 10786815 |
| Melanoma |
Primary "in situ" | 0/20 (0%) | IHC mAB 57B | |
| Melanoma |
Primary invasive | 17/65 (26%) | IHC mAB 57B | |
| Nevus |
0/132 (0%) | IHC mAB 57B | ||
| Cellular blue nevus |
0/8 (0%) | IHC mAB 57B | 15024190 | |
| Cellular blue nevus with microalveolar pattern |
2/3 (67%) | IHC mAB 57B | ||
| Clonal nevus |
28/30 (93%) | IHC mAB 57B | ||
| Common blue nevus |
5/17 (29%) | IHC mAB 57B | ||
| Deep penetrating nevus |
6/6 (100%) | IHC mAB 57B | ||
| Desmoplastic cellular blue nevus |
1/6 (17%) | IHC mAB 57B | ||
| Desmoplastic nevus |
2/9 (22%) | IHC mAB 57B | ||
| Epithelioid blue nevus |
� (50%) | IHC mAB 57B | ||
| Halo nevus |
5/10 (50%) | IHC mAB 57B | ||
| Persistent melanocytic nevus |
2/12 (17%) | IHC mAB 57B | ||
| Sclerotic blue nevus |
0/3 (0%) | IHC mAB 57B | ||
| Melanoma |
15/56 (27%) | IHC AB MAGE-1 (NeoMarkers) | 15223957 | |
| Melanoma |
Metastatic tumor | 113/191 (59.1%) | IHC mAB 77B | 16567969 |
| Melanoma |
6 / 31 (19%) | FACS | 15305155 | |
| Melanoma |
96/321 (30%) | IHC | 21115342 |
OTHER CANCER Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Gastrointestinal stromal tumor (GIST) |
5/35 (14%) | IHC | 19190130 |
Ovarian cancer Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Ovarian carcinoma |
3/5 (60%) | IHC mAB 57B | 10699915 |
Sarcoma Show
| Tumor Subtype | Sample type | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Gastrointestinal stromal tumor (GIST) |
5/35 (14%) | IHC | 18646188 |
Testicular cancer Show
Published data of protein expression in Cell Lines
Show| Origin tissue | Cell Line ID | Frequency | Methodology | PMID |
|---|---|---|---|---|
| Brain tumor- Glioma | A172 D-54 LN18 LN229 LNZ308 SF767 SNB19 T98G U-118 U-251 U-373 U-87 |
12/12 (100%) | FACS | 17255279 |
| Melanoma | WM3130-A | 1/1 (100%) | Western blot and Immunofluorescence | 18205182 |
| Melanoma stem cells (MSC) | WM3130-NA | 1/1 (100%) | Western blot and Immunofluorescence | 18205182 |
| Osteosarcoma | U-2OS Saos-2 Zos Zos-M MG-63 IOR/OS9 |
Western blot | 22009167 |
Available antibodies
MA454 monoclonal antibody Chen et al, 1994 PMID: 8302824
77B monoclonal antibody Schultz-Thater et al, 1994 PMID: 7927954
57B monoclonal antibody Kocher et al, 1995 PMID: 7757970 (detects several MAGE-A antigens)
6C1 monoclonal antibody Carrel et al, 1996 PMID: 8707418 (detects several MAGE-A antigens)
2005-2009© CT Antigens Database