| 1 |
09/01/2007 |
17686055 |
Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition. |
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Azacitidine and decitabine are cytidine analogues that inhibit DNA methylation, and are used to treat myeloid haematological malignancies. Hydroxycarbamide (HC) (also known as hydroxyurea), a ribonucl...
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| 2 |
09/01/2006 |
16951217 |
Unique tumor antigens: evidence for immune control of genome integrity and immunogenic targets for T cell-mediated patient-specific immunotherapy. |
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The molecular identification and characterization of antigenic epitopes recognized by T cells on human cancers has rapidly evolved since the cloning in 1991 of MAGEA1, the first gene reported to encod...
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| 3 |
09/01/2006 |
16951158 |
Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. |
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Genome-wide reduction in 5-methylcytosine is an epigenetic hallmark of human tumorigenesis. Experimentally induced hypomethylation in mice promotes genomic instability and is sufficient to initiate tu...
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| 4 |
07/01/2006 |
16773189 |
Expression of RHAMM/CD168 and other tumor-associated antigens in patients with B-cell chronic lymphocytic leukemia. |
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Antigen targeted immunotherapies might represent a novel treatment for B-cell chronic lymphocytic leukemia (B-CLL). We screened the mRNA expression of tumor-associated antigens (TAAs) from the literat...
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| 5 |
01/01/2006 |
16720928 |
Dendritic cells, pulsed with lysate of allogeneic tumor cells, are capable of stimulating MHC-restricted antigen-specific antitumor T cells. |
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A variety of approaches have been used to deliver tumor-associated antigens (TAA) in conjunction with dendritic cells (DC) as cellular adjuvants. DC derived from monocytic precursors have been pulsed ...
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| 6 |
05/01/2005 |
15672408 |
Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors. |
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Testicular germ-cell tumors (TGCTs) are pluripotent and display protean histology from the germ-cell stage until embryonal and somatic-cell differentiation. These properties make TGCT a fascinating mo...
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| 7 |
12/01/2004 |
15526363 |
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. |
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AIM: To establish the methylation profile of the promoter CpG islands of 31 genes that might play etiological roles in colon carcinogenesis. METHODS: The methylation specific PCR in conjunction of seq...
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| 8 |
09/14/2004 |
15367334 |
Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. |
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BACKGROUND: Astrocytoma is a common aggressive intracranial tumor and presents a formidable challenge in the clinic. Association of altered DNA methylation patterns of the promoter CpG islands with th...
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| 9 |
07/15/2004 |
15237429 |
Expression of cancer-testis antigens in hepatocellular carcinoma. |
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AIM: To investigate the expression of cancer-testis (CT) antigens MAGE-1, SSX-1,CTp11 and HCA587 genes in hepatocellular carcinoma (HCC) and the possibility of applying these antigens as targets for s...
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| 10 |
03/01/2004 |
15160996 |
Cytotoxic T cell induction against human malignant melanoma cells using HLA-A24-restricted melanoma peptide cocktail. |
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Many human leukocyte antigen (HLA)-class I (mainly A*0201)-restricted peptide-specific cytotoxic T cells (CTLs) have been derived from peripheral blood lymphocytes (PBLs) of melanoma patients. However...
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| 11 |
10/01/2003 |
14672555 |
Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. |
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To determine the possible role of the epigenetic mechanisms in carcinogenesis of the hepatocellular carcinoma, we methylation-profiled the promoter CpG islands of twenty four genes both in HCC tumors ...
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| 12 |
01/01/2003 |
14716063 |
MAGE1 is expressed by a subset of pancreatic endocrine neoplasms and associated lymph node and liver metastases. |
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BACKGROUND: MAGE1 was originally isolated from human melanoma cells as a target antigen for autologous cytotoxic T lymphocytes. Expression of MAGE1 has subsequently been identified in a number of neop...
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| 13 |
01/01/2003 |
12660449 |
Identification and quantification of antigens associated with HLA class I molecules on a bladder tumour cell line. Implications for vaccine design. |
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The aim of this study was to isolate and identify antigenic peptides associated with HLA class I molecules on a bladder tumour cell line. HLA-A1 molecules were purified using an immunobead-purificatio...
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| 14 |
07/01/2002 |
12378152 |
[Antitumor vaccines: conception, development and evaluation in humans] |
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Our strategy is to develop multivalent recombinant vaccines capable of eliciting broad immune responses in patients with malignant melanoma or colorectal cancer. Our current focus is on the induction ...
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| 15 |
01/01/2002 |
11952287 |
Molecular analyses of sentinel lymph nodes: an open question. |
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AIMS: To detect micrometastases in the sentinel lymph nodes (SLN) of melanoma patients the authors analysed 52 lymph nodes (47 SLNs and five non-sentinel) and 17 corresponding primary skin melanomas u...
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| 16 |
11/01/2001 |
11604998 |
Quantitative assessment of the expression of melanoma-associated antigens by non-competitive reverse transcription polymerase chain reaction. |
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The assessment of tumor-associated antigens (TAA) recognized by T lymphocytes is a prerequisite for diagnosis and immunotherapy of melanoma. Different reverse transcription-polymerase chain reaction (...
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| 17 |
05/01/2000 |
10767368 |
Selection of mRNA markers for detection of lymph node micrometastases in breast cancer patients. |
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The aim of this study was to search for specific and sensitive mRNA markers or a combination of markers for RT-PCR detection of micrometastases in axillary lymph nodes (LNs) from patients with breast ...
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| 18 |
08/31/1999 |
10515601 |
Effective immunotherapy of cancer by DNA vaccination. |
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Direct injection of naked plasmid DNA either intramuscularly or intradermally induces strong, long-lived cell-mediated and humoral immune responses to the antigen encoded by the gene vaccine. In the p...
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| 19 |
08/01/1999 |
10500969 |
[Molecular staging of testicular cancer using polymerase chain reaction of the testicular cancer-specific genes] |
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Most testicular germ cell tumors have serological tumor markers such as alpha-fetoprotein (AFP) and human chorionic gonadotropin beta-subunit (beta-HCG). On the other hand, molecular staging of these ...
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| 20 |
02/01/1999 |
10099984 |
Flow cytometry isolation and reverse transcriptase-polymerase chain reaction characterization of human round spermatids in infertile patients. |
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Flow cytometry coupled to cell sorting is proposed as a method to isolate round spermatids from testicular biopsies in obstructive azoospermic patients. The cells were separated on the basis of their ...
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