| 1 |
11/23/2007 |
18037669 |
Sperm aneuploidy and meiotic sex chromosome configurations in an infertile XYY male. |
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BACKGROUND There is little information regarding the behaviour of the extra Y chromosome during meiosis I in men with 47,XYY karyotypes and the segregation of the sex chromosomes in sperm. We applied ...
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| 2 |
11/06/2007 |
17997150 |
Disruption of pairing and synapsis of chromosomes causes stage-specific apoptosis of male meiotic cells. |
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During meiosis, DNA replication is followed by two successive rounds of chromosome segregation (meiosis I and II), which give rise to genetically diverse haploid gametes. The prophase of the first mei...
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| 3 |
11/02/2007 |
17983272 |
Meiotic Pairing and Segregation of Achiasmate Sex Chromosomes in Eutherian Mammals: The Role of SYCP3 Protein. |
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In most eutherian mammals, sex chromosomes synapse and recombine during male meiosis in a small region called pseudoautosomal region. However in some species sex chromosomes do not synapse, and how th...
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| 4 |
10/23/2007 |
17939997 |
Chromosome mobility during meiotic prophase in Saccharomyces cerevisiae. |
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In many organisms, a synaptonemal complex (SC) intimately connects each pair of homologous chromosomes during much of the first meiotic prophase and is thought to play a role in regulating recombinati...
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| 5 |
10/18/2007 |
17947423 |
The Formation of the Central Element of Synaptonemal Complex May Occur By Multiple Mechanisms: The Roles of the N- and C-Terminal Domains of the Drosophila C(3)G Protein in Mediating Synapsis and Recombination. |
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In Drosophila melanogaster oocytes, the C(3)G protein comprises the transverse filaments (TFs) of the synaptonemal complex (SC). Like other TF proteins, such as Zip1p in yeast and SCP1 in mammals, C(3...
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| 6 |
06/01/2007 |
17428461 |
Germline stem cells and neo-oogenesis in the adult human ovary. |
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It remains unclear whether neo-oogenesis occurs in postnatal ovaries of mammals, based on studies in mice. We thought to test whether adult human ovaries contain germline stem cells (GSCs) and undergo...
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| 7 |
05/01/2007 |
17326804 |
Identification of essential genes for linear replication of an SCP1 composite plasmid. |
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The 365 023 bp linear plasmid Streptomyces coelicolor plasmid 1 (SCP1) of S. coelicolor A3(2) belongs to the model systems of actinomycetes linear plasmids. Although the plasmid was detected more than...
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| 8 |
03/12/2007 |
17339376 |
SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination. |
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Synapsis is the process by which paired chromosome homologues closely associate in meiosis before crossover. In the synaptonemal complex (SC), axial elements of each homologue connect through molecule...
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| 9 |
03/01/2007 |
17367390 |
The telomere system of the Streptomyces linear plasmid SCP1 represents a novel class. |
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Linear plasmids and chromosomes of Streptomyces carry terminal proteins (TPs) covalently attached to the 5' ends of the DNA. Most known telomeres are conserved in primary sequence and in the potential...
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| 10 |
01/01/2007 |
17846907 |
Protein immunolocalization supports the presence of identical mechanisms of XY body formation in eutherians and marsupials. |
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The meiotic sex chromosomes of the American marsupials Monodelphis dimidiata and Didelphis albiventris were studied with electron microscopy (EM) and with immunofluorescence localization of meiotic pr...
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| 11 |
01/01/2007 |
17674146 |
Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis. |
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During meiosis the programmed induction of DNA double-stranded breaks (DSB) leads to crossover (CO) and non-crossover products (NCO). One key role of CO is to connect homologs before metaphase I and t...
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| 12 |
11/01/2006 |
16775250 |
The Sycp1-Cre transgenic mouse and male germ cell inhibition of NF-kappa b. |
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Successful spermatogenesis requires autocrine, paracrine, and endocrine signaling throughout the testes. The seminiferous tubules contain somatic Sertoli cells in tight association with numerous germ ...
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| 13 |
10/01/2006 |
16968740 |
Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. |
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During the first meiotic prophase, alignment and synapsis of the homologous chromosomes are mediated by the synaptonemal complex. Incorrect assembly of this complex results in cell death, impaired mei...
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| 14 |
09/01/2006 |
16929165 |
Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. |
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Cancer-Testis (CT) antigens are by definition expressed in tumor but not in healthy tissue except testis and might represent ideal targets for antigen-specific immunotherapy. Here, we present the firs...
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| 15 |
08/25/2006 |
16934004 |
Involvement of synaptonemal complex proteins in sex chromosome segregation during marsupial male meiosis. |
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Marsupial sex chromosomes break the rule that recombination during first meiotic prophase is necessary to ensure reductional segregation during first meiotic division. It is widely accepted that in ma...
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| 16 |
08/01/2006 |
16803849 |
Variation in MLH1 distribution in recombination maps for individual chromosomes from human males. |
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Meiotic recombination is essential for the segregation of homologous chromosomes and the formation of normal haploid gametes. Little is known about patterns of meiotic recombination in human germ cell...
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| 17 |
08/01/2006 |
16764855 |
Structural components of the synaptonemal complex, SYCP1 and SYCP3, in the medaka fish Oryzias latipes. |
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The synaptonemal complex (SC) is a meiosis-specific structure essential for synapsis of homologous chromosomes. For the first time in any non-mammalian vertebrates, we have isolated cDNA clones encodi...
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| 18 |
08/01/2006 |
16644921 |
Mouse embryonic stem cells form follicle-like ovarian structures but do not progress through meiosis. |
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Several recent studies have suggested that mouse embryonic stem cells (ESCs) can differentiate into female and male germ cells in vitro. The meiotic process in germ cell-like cells derived from ESCs h...
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| 19 |
06/21/2006 |
16724108 |
Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. |
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Small carboxyl-terminal domain (CTD) phosphatase 2 (SCP2) was identified and verified as a protein that interacts with the androgen receptor (AR). Ectopic expression of SCP2 or two other family member...
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| 20 |
06/20/2006 |
16766662 |
Two levels of interference in mouse meiotic recombination. |
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During meiosis, homologous chromosomes (homologs) undergo recombinational interactions, which can yield crossovers (COs) or noncrossovers. COs exhibit interference; they are more evenly spaced along t...
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