1 |
09/01/2007 |
17553591 |
Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: different cytogenetic changes are correlated with genders and smoking habits. |
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Chromosomal aberrations of malignant cells from pleural effusions of 31 cases of lung adenocarcinoma were analyzed. Pooled CGH results showed frequent amplifications on chromosome arms 1p (22.6%), 1q ...
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2 |
09/01/2006 |
16929165 |
Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. |
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Cancer-Testis (CT) antigens are by definition expressed in tumor but not in healthy tissue except testis and might represent ideal targets for antigen-specific immunotherapy. Here, we present the firs...
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3 |
08/01/2006 |
17178662 |
Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? |
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We evaluated the significance of lactate dehydrogenase (LDH) isoenzymes in chronic myeloproliferative disorders (CMDs) by studying LDH isoenzymes in the serum of patients with secondary polycythemia (...
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4 |
07/01/2006 |
16582413 |
Testis-specific lactate dehydrogenase (LDH-C4; Ldh3) in murine oocytes and preimplantation embryos. |
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LDH-C(4) (Ldh3) is a member of the lactate dehydrogenase family of isozymes that catalyze the terminal reaction in the glycolytic pathway. In mammals, 3 genes, ldha, ldhb, and Ldhc, encode the subunit...
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5 |
05/15/2006 |
16353146 |
Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer. |
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Cancer/germline (CG) antigens represent promising targets for widely applicable mono- and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC). Since little is known about their composit...
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6 |
01/01/2006 |
16397242 |
Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. |
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Spermatocytic seminomas are solid tumors found solely in the testis of predominantly elderly individuals. We investigated these tumors using a genome-wide analysis for structural and numerical chromos...
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7 |
04/01/2005 |
15966667 |
[Serum lactate dehydrogenase and its isoenzymes in nasopharyngeal carcinoma in Tunisia] |
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Our prospective study interested 41 patients, from 13 to 70 years old, and present a nasopharyngeal carcinoma confirmed histologically, during the period going from September 1999 to March 2000, and 4...
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8 |
05/15/2004 |
15133854 |
Establishment and characterization of human hepatocellular carcinoma cell line FHCC-98. |
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AIM: To establish a novel human hepatocellular carcinoma (HCC) cell line FHCC-98 from HCC tissue and to provide a suitable model for studying HCC occurrence, progress and metastasis. METHODS: Serially...
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9 |
05/01/2004 |
14985855 |
A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications. |
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Spermatogenesis is an essential stage in the human reproductive process. In a previously study aiming to determine which genes might be involved in spermatogenesis, we compared the gene expression pro...
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10 |
11/01/2003 |
14581519 |
Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene. |
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We have cloned and sequenced the entire mouse ldhc gene and mapped it physically in relation to the somatic ldha gene. The 2 genes were found to be oriented in head-to-tail fashion with about a 6-kilo...
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11 |
11/15/2002 |
12438276 |
Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer. |
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We applied a combined data mining and experimental validation Approach for the discovery of germ cell-specific genes aberrantly expressed in cancer. Six of 21 genes with confirmed germ cell specificit...
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12 |
09/21/2001 |
11447215 |
ldhc expression in non-germ cell nuclei is repressed by NF-I binding. |
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Developmental and testis-specific expression of the mouse lactate dehydrogenase C (mldhc) gene requires mechanisms for activation in germ cells and repression in somatic cells. Promoter activity restr...
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13 |
01/25/2000 |
10721707 |
cDNA cloning of pig testicular lactate dehydrogenase-C, thermal stability of the expressed enzyme, and polymorphism among strains. |
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Pig testicular lactate dehydrogenase-C (LDHC) cDNA was cloned and sequenced. The deduced sequence of 332 amino acids from pig LDHC shows 73% and 67% identity with that of pig LDHA (muscle) and LDHB (h...
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14 |
11/20/1998 |
9813024 |
Transgenic mice demonstrate a testis-specific promoter for lactate dehydrogenase, LDHC. |
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The mammalian genome encodes a family of lactate dehydrogenase (LDH) isozymes. Two of these, ldha and ldhb, are expressed ubiquitously. The ldhc gene is active only in the germinal epithelium during s...
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15 |
09/01/1998 |
9723174 |
Human testis-specific lactate dehydrogenase-C promoter drives overexpression of mouse lactate dehydrogenase-1 cDNA in testes of transgenic mice. |
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The three isozymes of lactate dehydrogenase, each encoded by a separate gene, are developmentally regulated and differentially expressed in tissue-specific patterns. The lactate dehydrogenase-C (LDHC,...
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16 |
05/01/1997 |
9222698 |
The characteristics of hepatocellular carcinoma with a high level of serum lactic dehydrogenase: a case report. |
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Hepatocellular carcinoma (HCC) remains one of the most important malignancies in Japan (1, 2). Lactic dehydrogenase (LDH), which is a glycolyticenzyme, and exists in various types of human tissue and ...
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17 |
02/01/1993 |
8439765 |
Changes in lactate dehydrogenase isoenzyme pattern in patients with tumors of the central nervous system. |
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Lactate dehydrogenase (LDH) isoenzymes were studied in biopsy samples obtained from 100 benign and malignant brain tumors. Diagnosis was confirmed by histopathology. It is observed that all tumors inv...
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18 |
07/01/1989 |
2596827 |
Regional localization of the sperm-specific lactate dehydrogenase, LDHC, gene on human chromosome 11. |
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A cDNA clone complementary to the mRNA encoding the sperm-specific lactate dehydrogenase, LDHC, has been used to map the LDHC locus to the short arm of human chromosome 11. In situ hybridization data ...
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19 |
09/01/1988 |
3175768 |
Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5. |
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The human gene coding for lactate dehydrogenase C (LDHC), a testis-specific isozyme, has been assigned to a refined region of chromosome 11, p14.3-p15.5, in which the lactate dehydrogenase A gene (LDH...
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20 |
01/01/1988 |
3180843 |
Mapping of human lactate dehydrogenase-A, -B, and -C genes and their related sequences: the gene for LDHC is located with that for LDHA on chromosome 11. |
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Human testis-specific lactate dehydrogenase-C (LDHC) gene-related sequences are located with the LDHA gene on chromosome 11. The LDHB gene is on chromosome 12. Chromosomes 1, 2, 4, 9, and 10 appear to...
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