1 |
07/24/2007 |
17650306 |
Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses. |
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ABSTRACT: INTRODUCTION: Cancer-testis antigens (CTAGs) are expressed solely in germ cells and in malignant tissues. They are targets of immune responses mediated by cytotoxic T cells in some cancers, ...
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2 |
02/01/2007 |
17023585 |
Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. |
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Immunotherapies using cancer-testis (CT) antigens as targets represent a potentially useful treatment in patients with multiple myeloma (MM) who commonly show recurrent disease following chemotherapy....
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3 |
12/01/2006 |
17157168 |
Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8+ T-cell responses and are lacking costimulatory molecules. |
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Specific immunotherapies for patients with chronic myeloid leukemia (CML) might eliminate residual CML cells after therapy with imatinib or chemotherapy and might enhance a specific graft-versus-leuke...
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4 |
09/01/2006 |
16929165 |
Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. |
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Cancer-Testis (CT) antigens are by definition expressed in tumor but not in healthy tissue except testis and might represent ideal targets for antigen-specific immunotherapy. Here, we present the firs...
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5 |
07/01/2006 |
16773189 |
Expression of RHAMM/CD168 and other tumor-associated antigens in patients with B-cell chronic lymphocytic leukemia. |
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Antigen targeted immunotherapies might represent a novel treatment for B-cell chronic lymphocytic leukemia (B-CLL). We screened the mRNA expression of tumor-associated antigens (TAAs) from the literat...
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6 |
12/01/2005 |
16734221 |
Cancer-testis antigen expression in bladder cancer. |
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PURPOSE: To evaluate the potential of cCancer-t/Testis antigens (CTAs) as targets for immunotherapy of bladder cancer, we evaluated the expression of 9 CTA genes or families of genes in normal urothel...
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7 |
05/01/2005 |
15704127 |
Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. |
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The BAGE (B melanoma antigens) sequence family contains 15 nearly identical sequences that are in the juxtacentromeric regions of chromosomes 9, 13, 18, and 21. BAGE loci are expressed in male germ ti...
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8 |
02/01/2005 |
15683221 |
Identification of cancer-testis genes expressed by melanoma and soft tissue sarcoma using bioinformatics. |
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Cancer-testis or germ cell antigens (GCAs) are a category of tumor antigens expressed by male germ cells and by cancers of diverse histological origin, but not usually by normal adult somatic tissue. ...
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9 |
07/01/2004 |
15201976 |
Prognostic significance of cancer-testis gene expression in resected non-small cell lung cancer patients. |
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MAGE, BAGE and GAGE genes encode T cell-defined tumor-associated antigens (TAA), which are expressed by various human tumors and are silent in normal tissues. Because of their expression pattern these...
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10 |
02/20/2004 |
14696097 |
mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies. |
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Specific immunotherapies for patients with acute myeloid leukemia (AML) using leukemia-associated antigens (LAA) as target structures might be a therapeutic option to enhance the graft-vs.-leukemia ef...
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11 |
10/01/2003 |
14512184 |
Expression of cancer/testis (CT) antigens in lung cancer. |
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Cancer/testis (CT) antigens are considered promising candidates for vaccine-based immunotherapy. The aim of this study was to investigate which CT antigens should be targeted in immunotherapy of Japan...
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12 |
08/01/2003 |
12890744 |
Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. |
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AIMS: Molecular genetic changes involved in tumorigenesis and malignant transformation of human tumours are novel targets of cancer diagnosis and treatment. This study aimed to analyse the expression ...
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13 |
04/01/2003 |
12676563 |
BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. |
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In this paper, we show that the BAGE (B melanoma antigen) gene family was generated by chromosome rearrangements that occurred during the evolution of hominoids. An 84-kb DNA fragment derived from the...
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14 |
03/01/2003 |
12681058 |
[Expression of MAGE, GAGE, and BAGE genes in human hepatocellular carcinoma] |
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OBJECTIVE: To observe the expression of MAGE, GAGE and BAGE genes in human hepatocellular carcinoma (HCC) cell lines. METHODS: The expression levels of MAGE-1, MAGE-3, GAGE1-8, GAGE1-2 and BAGE mRNAs ...
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15 |
02/01/2003 |
12574209 |
Analysis of cancer/testis antigens in sporadic medullary thyroid carcinoma: expression and humoral response to NY-ESO-1. |
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Cancer/testis antigens (CTA) are tumor-associated antigens expressed during ontogenesis, in a number of solid tumors but not in normal tissues except testis. Most of these CTA are highly immunogenic, ...
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16 |
01/01/2003 |
12759544 |
Expression of cancer/testis tumor associated antigens in cervical squamous cell carcinoma. |
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We investigated the expression of tumor-associated antigens (TAA) of the cancer/testis (C/T) gene family in cervical squamous cell carcinomas. First, we focused on the HeLa cervical cancer derived cel...
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17 |
12/01/2002 |
12461691 |
New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. |
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A first BAGE (B melanoma antigen) gene, BAGE1, was identified because it encodes a human tumour antigen recognised by a cytolytic T lymphocyte. Here, we characterised five new BAGE genes mapping to th...
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18 |
11/01/2002 |
14607688 |
Expression of A, G and B melanoma antigen genes in human hepatocellular carcinoma. |
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OBJECTIVE: To observe the expression of the A melanoma antigen (MAGE), G melanoma antigen (GAGE) and B melanoma antigen (BAGE) genes in human hepatocellular carcinoma cell lines. METHODS: The MAGE-1,M...
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19 |
11/01/2002 |
12399967 |
Frequent expression of HAGE in presentation chronic myeloid leukaemias. |
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Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these i...
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20 |
08/01/2002 |
12171503 |
Cancer-testis antigens: promising targets for antigen directed antineoplastic immunotherapy. |
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During the last decade, the aberrant expression of normal testicular proteins in neoplastically transformed cells became common knowledge. Cancer-testis antigens (CTAs) represent a novel family of imm...
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